Current Research

rTMS Study

Brain with Puzzle Pieces

Eligibility: 

  • Between 12-18 years old
  • Diagnosis of Major Depressive Disorder (MDD)
  • Experiencing a current MDD episode with a duration of ≥ 4 weeks and ≤3 years
  • Resistance to treatment (i.e. failure to respond to at least 1 antidepressant treatment

About the Study: 

Transcranial magnetic stimulation (TMS) is a non-surgical procedure used in the treatment of adults with depression that has not responded to anti-depressant medication (treatment-resistant depression; TRD). TMS uses fluctuating magnetic fields to increase frontal lobe brain activity with the goal of reducing depression symptoms. It was approved by the U.S. Food & Drug Administration in 2008 to treat TRD in adults. Very little research has been done testing this intervention for treatment-resistant depression in young people. The purpose of this study is to measure the feasibility, tolerability, and efficacy of a 6-week course of repetitive TMS in adolescents with depression that has not improved after treatment with at least one antidepressant medication. We are also studying the neurobiological mechanisms and predictors of response to rTMS with Magnetic Resonance Imaging (MRI).

For more information, please visit our page dedicated to the rTMS Study

BRIDGES Study

teen girls

Eligibility: 

  • 12-14 years old
  • Female 
  • Already had first menstrual cycle 

About the Study: 

During adolescence, the brain undergoes major change. We are working to better understand brain development during early-to-mid adolescence. In particular, this study is focused on the brain systems that manage negative emotion, self-understanding, and impulse-control. BRIDGES is working to understand how self-injury (a common problem in teenagers) influences brain development by studying the change in the brain and behavior patterns over time in girls with versus without self-injury. 

For more information, please visit our page dedicated to the BRIDGES Study

Mood Disorders Study

Sad teen boy
NOT Recruiting New Participants 

Eligibility: 

INCLUSION CRITERIA (For Adolescents with Mood Disorders):

  • Aged 13-18 years old
  • Male or Female
  • Both child and parent/guardian are fluent in English
  • Has a diagnosis of a depressive disorder, a bipolar-spectrum disorder (e.g. bipolar disorder type 1 or type 2,  or bipolar disorder not otherwise specified), or unspecified mood disorder (Patient Group)

​INCLUSION CRITERIA (For Healthy Controls):

  • No history of any psychiatric disorders.
  • No first-degree relatives with major depression, bipolar disorder or schizophrenia.

About the Study: 

We know that the biology of mood disorders is very complex. The purpose of this study is to learn more about the biology of mood disorders in youth. Specifically, we are examining the relationships between the brain, how cells work, and stress hormones in youth with and without mood disorders.

For more information, please visit our page dedicated to the Mood Study