About the Study
Transcranial magnetic stimulation (TMS) is a non-surgical procedure used in the treatment of adults with depression that has not responded to anti-depressant medication (treatment-resistant depression; TRD). TMS uses fluctuating magnetic fields to increase frontal lobe brain activity with the goal of reducing depression symptoms. It was approved by the U.S. Food & Drug Administration in 2008 to treat TRD in adults. Very little research has been done testing this intervention for treatment-resistant depression in young people. The purpose of this study is to measure the feasibility, tolerability, and efficacy of a 6-week course of repetitive TMS in adolescents with depression that has not improved after treatment with at least one antidepressant medication. We are also studying the neurobiological mechanisms and predictors of response to rTMS with Magnetic Resonance Imaging (MRI). We are no longer recruiting participants for this study.